Journal article
Series Multiblood Pump Design With Dual Activation for Pediatric Patients With Heart Failure
ASAIO journal (1992), v 71(3)
11 Sep 2024
PMID: 39255348
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The translational development of pediatric ventricular assist devices (VADs) lags years behind adult device options, negatively impacting pediatric patient outcomes. To address this need, we are developing a novel, series-flow, double-blood pump VAD that integrates an axial and centrifugal pump into a single device. The axial pump is used for initial circulatory assistance in younger patients; then, an internal activation mechanism triggers the centrifugal pump to activate in line with the axial pump, providing additional pressure and flow to match pediatric patient growth cycles. Here, we focused on the design and improvement of the device flow paths through computational analysis and in vitro hydraulic testing of a prototype. We estimated pressure-flow generation, fluid scalar stresses, and blood damage levels. In vitro hydraulic tests correlated well with shear stress transport (SST) predictions, with an average deviation of 4.5% for the complex, combined flow path. All data followed expected pump performance trends. The device exceeded target levels for blood damage in the blade tip clearances, and this must be both investigated and addressed in the next design phase. These study findings establish a strong foundation for the future development of the Drexel Double-Dragon VAD .
Metrics
Details
- Title
- Series Multiblood Pump Design With Dual Activation for Pediatric Patients With Heart Failure
- Creators
- Thomas C. Palazzolo - Drexel UniversityHarutyun Sarkisyan - Drexel UniversityGiselle C. Matlis - Drexel UniversityJordon McGowan - BioCirc Research Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PennsylvaniaVakhtang Tchantchaleishvili - Thomas Jefferson UniversityRandy M. Stevens - Drexel UniversityAmy L. Throckmorton - Drexel University
- Publication Details
- ASAIO journal (1992), v 71(3)
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS; PHILADELPHIA
- Number of pages
- 9
- Grant note
- Drexel University's "Research and Engineering for Pediatrics by Interdisciplinary Collaboration Leveraging Education and Partnerships for Pediatric Healthcare (R-EPIC LEAP for Pediatric Healthcare)" from the U.SDepartment of Education's Graduate Assistance in Areas of National Need ProgramAmerican Heart Association Predoctoral Fellowship Award: 24PRE1189261 National Heart, Lung, and Blood Institute of the National Institutes of Health: R01HL153536
The authors wish to acknowledge the financial support as provided by partial support from the Drexel University's "Research and Engineering for Pediatrics by Interdisciplinary Collaboration Leveraging Education and Partnerships for Pediatric Healthcare (R-EPIC LEAP for Pediatric Healthcare)" from the U.S. Department of Education's Graduate Assistance in Areas of National Need Program (Fellowship Award: T.C.P.) and an American Heart Association Predoctoral Fellowship Award (24PRE1189261: T.C.P.). A portion of this research reported in this publication was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health, under Award Number: R01HL153536. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:001432574300015
- Scopus ID
- 2-s2.0-85204096841
- Other Identifier
- 991021902494004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Transplantation