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Successful treatment of choroidal neovascular membrane in retinitis pigmentosa with intravitreal bevacizumab
Journal article   Peer reviewed

Successful treatment of choroidal neovascular membrane in retinitis pigmentosa with intravitreal bevacizumab

Archana Malik, Sunandan Sood and Subina Narang
International ophthalmology, v 30(4), pp 425-428
Aug 2010
PMID: 20049508

Abstract

Adult Angiogenesis Inhibitors - administration & dosage Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal, Humanized Bevacizumab Choroidal Neovascularization - diagnosis Choroidal Neovascularization - drug therapy Choroidal Neovascularization - etiology Fundus Oculi Humans Injections, Intraocular Male Retinitis Pigmentosa - complications Tomography, Optical Coherence Treatment Outcome Vitreous Body
We report a rare association of choroidal neovascularization (CNV) with retinitis pigmentosa and note its resolution by intravitreal injection of the anti-vascular endothelial growth factor (VEGF), bevacizumab. A classic choroidal neovascular membrane was seen in the right eye (RE) of a patient with sector retinitis pigmentosa. Bevacizumab 1.25 mg in 0.05 ml was injected intravitreally. The choroidal neovascular membrane was seen to regress following this single intravitreal bevacizumab injection with formation of a scar. CNV has very rarely been seen in association with retinitis pigmentosa. Anti-VEGF drugs have been shown to have a beneficial role in CNV with other causes; in this case their effectiveness in CNV associated with retinal dystrophies, for example retinitis pigmentosa, has been demonstrated.

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