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Journal article
Superior myocardial preservation with modified UW solution after prolonged ischemia in the rat heart
The Annals of thoracic surgery, v 49(6), pp 932-939
01 Jun 1990
PMID: 2369191
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Abstract
Cardiac transplantation remains constrained by poor graft tolerance of prolonged cold ischemia. University of Wisconsin solution has remarkably extended ischemic preservation in pancreas, kidney, and liver transplantation. To assess its efficacy in cardiac preservation, modified University of Wisconsin solution flush and storage were tested against St. Thomas' cardioplegia flush and normal saline solution storage after six hours of ischemia at 0 °C in 46 isolated rat hearts. After ischemia, groups were compared before and after reperfusion. After ischemia but before reperfusion. University of Wisconsin solution hearts had significantly less tissue water (3.8%), superior tissue sodium, potassium, calcium, and magnesium profiles, and elevated adenosine and inosine levels, and tended toward better histological preservation. After reperfusion, University of Wisconsin solution more effectively preserved left ventricular compliance (75% versus 35% of baseline), developed pressure (71% versus 45% of baseline), histological integrity, and tissue potassium and calcium profiles than St. Thomas' solution. The University of Wisconsin solution provided superior preservation of systolic and diastolic ventricular function, tissue histology, tissue water, and tissue electrolytes than did St. Thomas' cardioplegia and normal saline solution storage in this experimental model, and might result in improved graft tolerance of ischemia in clinical cardiac transplantation.
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Details
- Title
- Superior myocardial preservation with modified UW solution after prolonged ischemia in the rat heart
- Creators
- Thomas YehScott A. HananDanna E. JohnsonIvan M. RebeykaAnwar S. Abd-ElfattahK.Francis LeeAndrew S. Wechsler
- Publication Details
- The Annals of thoracic surgery, v 49(6), pp 932-939
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; [Retired Faculty]
- Web of Science ID
- WOS:A1990DN23000014
- Scopus ID
- 2-s2.0-0025369656
- Other Identifier
- 991020705345304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Respiratory System
- Surgery