Journal article
Tau-Like Proteins in the Nervous System of Goldfish
Neurochemical research, v 22(12), pp 1511-1516
Dec 1997
PMID: 9357018
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This report describes the presence of a group of tau-like proteins (TLPs) in goldfish central nervous system. The TLPs were immunoreactive with antibodies that recognized the carboxy-terminal domain of mammalian tau, but not with antibodies that recognized the amino-terminus. The TLPs of goldfish exhibited the basic properties of tau proteins including neuronal specificity, structural heterogeneity, heat stability and the ability to co-assemble with tubulin. We propose that TLPs may represent a precursor of tau, that share the microtubule binding domain and the carboxy-terminal domain with mammalian tau proteins. In contrast the amino-terminus of the TLPs is much shorter and may represent a more variable domain of tau proteins.
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Details
- Title
- Tau-Like Proteins in the Nervous System of Goldfish
- Creators
- Yi Liu - Department of Neurobiology and Anatomy Allegheny University of the Health Sciences, Medical College of Pennsylvania and Hahnemann School of Medicine 3200 Henry Avenue Philadelphia Pennsylvania 19129Jun Xia - Department of Neurobiology and Anatomy Allegheny University of the Health Sciences, Medical College of Pennsylvania and Hahnemann School of Medicine 3200 Henry Avenue Philadelphia Pennsylvania 19129Dongling Ma - Department of Neurobiology and Anatomy Allegheny University of the Health Sciences, Medical College of Pennsylvania and Hahnemann School of Medicine 3200 Henry Avenue Philadelphia Pennsylvania 19129Donald Faber - Department of Neurobiology and Anatomy Allegheny University of the Health Sciences, Medical College of Pennsylvania and Hahnemann School of Medicine 3200 Henry Avenue Philadelphia Pennsylvania 19129Itzhak Fischer - Department of Neurobiology and Anatomy Allegheny University of the Health Sciences, Medical College of Pennsylvania and Hahnemann School of Medicine 3200 Henry Avenue Philadelphia Pennsylvania 19129
- Publication Details
- Neurochemical research, v 22(12), pp 1511-1516
- Publisher
- Kluwer Academic Publishers-Plenum Publishers; New York
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1997YD02000014
- Scopus ID
- 2-s2.0-0030778213
- Other Identifier
- 991014877872804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Neurosciences