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Accepted (AM)Open Access (License Unspecified), Open
Journal article
The Association Between Parental Age and Autism-Related Outcomes in Children at High Familial Risk for Autism
Autism research, v 13(6), pp 998-1010
Jun 2020
PMID: 32314879
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Advanced parental age is a well-replicated risk factor for autism spectrum disorder (ASD), a neurodevelopmental condition with a complex and not well-defined etiology. We sought to determine parental age associations with ASD-related outcomes in subjects at high familial risk for ASD. A total of 397 younger siblings of a child with ASD, drawn from existing prospective high familial risk cohorts, were included in these analyses. Overall, we did not observe significant associations of advanced parental age with clinical ASD diagnosis, Social Responsiveness Scale, or Vineland Adaptive Behavior Scales scores. Instead, increased odds of ASD were found with paternal age < 30 years (adjusted odds ratio [AOR] = 2.83 and 95% confidence intervals [CI] = 1.14-7.02). Likewise, younger age (<30 years) for both parents was associated with decreases in Mullen Scales of Early Learning early learning composite (MSEL-ELC) scores (adjusted β = -9.62, 95% CI = -17.1 to -2.15). We also found significant increases in cognitive functioning based on MSEL-ELC scores with increasing paternal age (adjusted β associated with a 10-year increase in paternal age = 5.51, 95% CI = 0.70-10.3). Results suggest the potential for a different relationship between parental age and ASD-related outcomes in families with elevated ASD risk than has been observed in general population samples. Autism Res 2020, 13: 998-1010. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Previous work suggests that older parents have a greater likelihood of having a child with autism. We investigated this relationship in the younger siblings of families who already had a child with autism. In this setting, we found a higher likelihood of autism, as well as poorer cognitive scores, in the siblings with younger fathers, and higher cognitive scores in the siblings with older parents. These results suggest that parental age associations may differ based on children's familial risk for autism.
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Details
- Title
- The Association Between Parental Age and Autism-Related Outcomes in Children at High Familial Risk for Autism
- Creators
- Kristen Lyall - Drexel UniversityLanxin Song - Johns Hopkins UniversityKelly Botteron - Washington University in St. LouisLisa A Croen - Kaiser PermanenteStephen R Dager - University of WashingtonM Daniele Fallin - BloombergHeather C Hazlett - University of North Carolina at Chapel HillElizabeth Kauffman - Drexel UniversityRebecca Landa - Kennedy Krieger InstituteChristine Ladd-Acosta - BloombergDaniel S Messinger - University of MiamiSally Ozonoff - MIND Institute, Department of Psychiatry and Behavioral Sciences, University of California Davis, Sacramento, California, USA.Juhi Pandey - University of PennsylvaniaJoseph Piven - University of North Carolina at Chapel HillRebecca J Schmidt - University of California, DavisRobert T Schultz - University of PennsylvaniaWendy L Stone - University of WashingtonCraig J Newschaffer - Pennsylvania State UniversityHeather E Volk - Bloomberg
- Publication Details
- Autism research, v 13(6), pp 998-1010
- Publisher
- Wiley
- Grant note
- P50 HD103524 / NICHD NIH HHS U54 HD086984 / NICHD NIH HHS R01 HD055741 / NICHD NIH HHS R01 ES028089 / NIEHS NIH HHS P01 ES011269 / NIEHS NIH HHS P30 ES023513 / NIEHS NIH HHS K12 HD051958 / NICHD NIH HHS UH3 OD023342 / NIH HHS R24 ES028533 / NIEHS NIH HHS UL1 TR000002 / NCATS NIH HHS R01 MH068398 / NIMH NIH HHS R01 ES016443 / NIEHS NIH HHS P50 HD103573 / NICHD NIH HHS R01 HD057284 / NICHD NIH HHS U54 HD079125 / NICHD NIH HHS R01 ES025574 / NIEHS NIH HHS AS5938 / Autism Speaks R01 ES020392 / NIEHS NIH HHS R01 MH059630 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000527034400001
- Scopus ID
- 2-s2.0-85083672680
- Other Identifier
- 991019168287504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Behavioral Sciences
- Psychology, Developmental