Journal article
The Changing Epidemiology of Autism Spectrum Disorders
Annual review of public health, v 38(1), pp 81-102
20 Mar 2017
PMID: 28068486
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with lifelong impacts. Genetic and environmental factors contribute to ASD etiology, which remains incompletely understood. Research on ASD epidemiology has made significant advances in the past decade. Current prevalence is estimated to be at least 1.5% in developed countries, with recent increases primarily among those without comorbid intellectual disability. Genetic studies have identified a number of rare de novo mutations and gained footing in the areas of polygenic risk, epigenetics, and gene-by-environment interaction. Epidemiologic investigations focused on nongenetic factors have established advanced parental age and preterm birth as ASD risk factors, indicated that prenatal exposure to air pollution and short interpregnancy interval are potential risk factors, and suggested the need for further exploration of certain prenatal nutrients, metabolic conditions, and exposure to endocrine-disrupting chemicals. We discuss future challenges and goals for ASD epidemiology as well as public health implications.
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Details
- Title
- The Changing Epidemiology of Autism Spectrum Disorders
- Creators
- Kristen Lyall - A.J. Drexel Autism Institute, Philadelphia, Pennsylvania 19104; email: cjn32@drexel.eduLisa Croen - Kaiser Permanente Division of Research, Oakland, California 94612Julie Daniels - Department of Epidemiology, University of North Carolina Gillings School of Public Health, Chapel Hill, North Carolina 27599M Daniele Fallin - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205Christine Ladd-Acosta - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205Brian K Lee - Department of Medical Epidemiology and Biostatistics and Department of Public Health Sciences, Karolinska Institute, SE 171-77 Stockholm, SwedenBo Y Park - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205Nathaniel W Snyder - A.J. Drexel Autism Institute, Philadelphia, Pennsylvania 19104; email: cjn32@drexel.eduDiana Schendel - Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, DenmarkHeather Volk - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205Gayle C Windham - California Department of Public Health, Division of Environmental and Occupational Disease Control, Richmond, California 94805Craig Newschaffer - A.J. Drexel Autism Institute, Philadelphia, Pennsylvania 19104; email: cjn32@drexel.edu
- Publication Details
- Annual review of public health, v 38(1), pp 81-102
- Publisher
- Annual Reviews; United States
- Grant note
- R21 HD087866 / NICHD NIH HHS R03 CA211820 / NCI NIH HHS K22 ES026235 / NIEHS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics; A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000404166400005
- Scopus ID
- 2-s2.0-85017178110
- Other Identifier
- 991014878006304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health