Journal article
The Effect of PEEP on Left Ventricular Diastolic Dimensions and Systolic Performance Following Myocardial Revascularization
The Annals of thoracic surgery, v 33(6), pp 585-592
Jun 1982
PMID: 7046658
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To quantitate the alterations in left ventricular (LV) dimensions and performance at successive levels of positive end-expiratory pressure (PEEP), 16 patients undergoing coronary artery bypass grafting (CABG) underwent instrumentation with ultrasonic dimension transducers to measure the minor-axis diameter of the left ventricle. Matched micromanometers were placed to measure intracavitary LV pressure and intrathoracic pressure. LV pressure and dimension data were recorded and computer analyzed during continuous positive-pressure ventilation at 0, 5, 10, and 15 cm H
2O of PEEP 4 to 8 hours postoperatively. Preload was determined by the end-diastolic minor-axis diameter, cardiac output was measured by thermodilution, and indices of LV contractility assessed included the maximal velocity of minor-axis shortening and the slope of the end-systolic pressure-diameter relationship.
PEEP produced a progressive increase in intrathoracic pressure associated with a fall in cardiac output; this was associated with a decrease in LV end-diastolic diameter and no significant change in the maximal velocity of minor-axis shortening or the slope of the end-systolic pressure-diameter relationship. Our results indicate that PEEP of 10 cm H
2O or greater will produce a significant fall in cardiac output in patients following CABG, due to a decrease in preload rather than impaired LV contractility.
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Details
- Title
- The Effect of PEEP on Left Ventricular Diastolic Dimensions and Systolic Performance Following Myocardial Revascularization
- Creators
- Peter Van Trigt - Duke Medical CenterThomas L. Spray - Duke Medical CenterMichael K. Pasque - Duke Medical CenterRobert B. Peyton - Duke Medical CenterGary L. Pellom - Duke Medical CenterCharles M. Christian - Duke Medical CenterLennart Fagraeus - Duke Medical CenterAndrew S. Wechsler - Duke Medical Center
- Publication Details
- The Annals of thoracic surgery, v 33(6), pp 585-592
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; [Retired Faculty]
- Web of Science ID
- WOS:A1982NT42300009
- Scopus ID
- 2-s2.0-0019998164
- Other Identifier
- 991020705319904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Respiratory System
- Surgery