Journal article
The Potential Adjuvanticity of CAvant(R)SOE for Foot-and-Mouth Disease Vaccine
Vaccines (Basel), v 9(10), p1091
01 Oct 2021
PMID: 34696199
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Foot-and-mouth disease (FMD) is a notifiable contagious disease of cloven-hoofed mammals. A high potency vaccine that stimulates the host immune response is the foremost strategy used to prevent disease persistence in endemic regions. FMD vaccines comprise inactivated virus antigens whose immunogenicity is potentiated by immunogenic adjuvants. Oil-based adjuvants have clear advantages over traditional adjuvant vaccines; however, there is potential to develop novel adjuvants to increase the potency of FMD vaccines. Thus, we aimed to evaluate the efficacy of a novel water-in-oil emulsion, called CAvant(R)SOE, as a novel vaccine adjuvant for use with inactivated FMD vaccines. In this study, we found that inactivated A22 Iraq virus plus CAvant(R)SOE (iA22 Iraq-CAvant(R)SOE) induced effective antigen-specific humoral (IgG, IgG1, and IgG2a) and cell-mediated immune responses (IFN-gamma and IL-4) in mice. Immunization of pigs with a single dose of iA22 Iraq-CAvant(R)SOE also elicited effective protection, with no detectable clinical symptoms against challenge with heterologous A/SKR/GP/2018 FMDV. Levels of protection are strongly in line with vaccine-induced neutralizing antibody titers. Collectively, these results indicate that CAvant(R)SOE-adjuvanted vaccine is a promising candidate for control of FMD in pigs.
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Details
- Title
- The Potential Adjuvanticity of CAvant(R)SOE for Foot-and-Mouth Disease Vaccine
- Creators
- Young-Hoon Ahn - Choong Ang Vaccine Laboratory Co., Ltd., Daejeon 34055, Korea.W. A. Gayan Chathuranga - Chungnam National UniversityYoung-Jung Shim - Choong Ang Vaccine Laboratory Co., Ltd., Daejeon 34055, Korea.D. K. Haluwana - Chungnam National UniversityEun-Hee Kim - Choong Ang Vaccine Laboratory Co., Ltd., Daejeon 34055, Korea.In-Joong Yoon - Choong Ang Vaccine Laboratory Co., Ltd., Daejeon 34055, Korea.Yong-Taik Lim - Sungkyunkwan UniversitySung Ho Shin - Plant (United States)Hyundong Jo - Animal and Plant Quarantine AgencySeong Yun Hwang - Plant (United States)Hyun Mi Kim - Plant (United States)Min Ja Lee - Plant (United States)Jong-Hyeon Park - Animal and Plant Quarantine AgencySung-Sik Yoo - Choong Ang Vaccine Lab Co Ltd, Daejeon 34055, South KoreaJong-Soo Lee - Chungnam National University
- Publication Details
- Vaccines (Basel), v 9(10), p1091
- Publisher
- Mdpi
- Number of pages
- 11
- Grant note
- 2018M3A9H4078692; 2018M3A9H4078703; 2021R1A6A1A03045495 / National Research Foundation of Korea (NRF) - Korea government (MEST); Ministry of Education, Science and Technology, Republic of Korea; National Research Foundation of Korea; Korean Government
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Arts and Sciences; Chemistry; Drexel University
- Web of Science ID
- WOS:000713186700001
- Scopus ID
- 2-s2.0-85116056294
- Other Identifier
- 991020100211304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Medicine, Research & Experimental