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Journal article
The Transcription Factor T-Bet Is Regulated by MicroRNA-155 in Murine Anti-Viral CD8+T Cells via SHIP-1
Frontiers in immunology, v 8, pp 1696-1696
06 Dec 2017
PMID: 29358931
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We report here that the expression of the transcription factor T-bet, which is known to be required for effector cytotoxic CD8(+) T lymphocytes (CTL) generation and effector memory cell formation, is regulated in CTL by microRNA-155 (miR-155). Importantly, we show that the proliferative effect of miR-155 on CD8(+) T cells is mediated by T-bet. T-bet levels in CTL were controlled in vivo by miR-155 via SH2 (Src homology 2)-containing inositol phosphatase-1 (SHIP-1), a known direct target of miR-155, and SHIP-1 directly downregulated T-bet. Our studies reveal an important and unexpected signaling axis between miR-155, T-bet, and SHIP-1 in in vivo CTL responses and suggest an important signaling module that regulates effector CTL immunity.
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Details
- Title
- The Transcription Factor T-Bet Is Regulated by MicroRNA-155 in Murine Anti-Viral CD8+T Cells via SHIP-1
- Creators
- Jennifer L. Hope - Erasmus MCChristopher J. Stairiker - Erasmus MCPanagiota I. Spantidea - Erasmus MCDonald T. Gracias - Drexel UniversityAlison J. Carey - Drexel UniversityAdam J. Fike - Drexel UniversityMarjan van Meurs - Erasmus MCInge Brouwers-Haspels - Erasmus MCLaurine C. Rijsbergen - Erasmus MCJoseph A. Fraietta - University of PennsylvaniaYvonne M. Mueller - Erasmus MCRosemarieke C. Klop - Erasmus MCErietta Stelekati - University of PennsylvaniaE. John Wherry - University of PennsylvaniaStefan J. Erkeland - Erasmus MCPeter D. Katsikis - Erasmus MC
- Publication Details
- Frontiers in immunology, v 8, pp 1696-1696
- Publisher
- Frontiers Media Sa
- Number of pages
- 14
- Grant note
- Erasmus University Medical Center R01 AI117718; AI105343; P01 AI108545; U19 AI082630; U19 AI117950 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Worldwide Cancer Research P01AI108545 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) T32CA009140 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Parker Institute
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Biology; Pediatrics
- Web of Science ID
- WOS:000417144900001
- Scopus ID
- 2-s2.0-85037342231
- Other Identifier
- 991019168437904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology