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The Transcription Factor T-Bet Is Regulated by MicroRNA-155 in Murine Anti-Viral CD8+T Cells via SHIP-1
Journal article   Open access   Peer reviewed

The Transcription Factor T-Bet Is Regulated by MicroRNA-155 in Murine Anti-Viral CD8+T Cells via SHIP-1

Jennifer L. Hope, Christopher J. Stairiker, Panagiota I. Spantidea, Donald T. Gracias, Alison J. Carey, Adam J. Fike, Marjan van Meurs, Inge Brouwers-Haspels, Laurine C. Rijsbergen, Joseph A. Fraietta, …
Frontiers in immunology, v 8, pp 1696-1696
06 Dec 2017
PMID: 29358931
url
https://doi.org/10.3389/fimmu.2017.01696View
Published, Version of Record (VoR)CC BY V4.0 Open

Abstract

Immunology Life Sciences & Biomedicine Science & Technology
We report here that the expression of the transcription factor T-bet, which is known to be required for effector cytotoxic CD8(+) T lymphocytes (CTL) generation and effector memory cell formation, is regulated in CTL by microRNA-155 (miR-155). Importantly, we show that the proliferative effect of miR-155 on CD8(+) T cells is mediated by T-bet. T-bet levels in CTL were controlled in vivo by miR-155 via SH2 (Src homology 2)-containing inositol phosphatase-1 (SHIP-1), a known direct target of miR-155, and SHIP-1 directly downregulated T-bet. Our studies reveal an important and unexpected signaling axis between miR-155, T-bet, and SHIP-1 in in vivo CTL responses and suggest an important signaling module that regulates effector CTL immunity.

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Immunology
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