Journal article
The association between prenatal oxidative stress levels measured by isoprostanes and offspring neurodevelopmental outcomes at 36 months
Brain, behavior, & immunity. Health, v 38, 100775
01 Jul 2024
PMID: 38706573
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Oxidative stress during pregnancy has been a mechanistic pathway implicated in autism development, yet few studies have examined this association directly. Here, we examined the association of prenatal levels of 8-isoPGF2 alpha, a widely used measure of oxidative stress, and several neurodevelopmental outcomes related to autism in children. Participants included 169 mother-child pairs from the Early Autism Risk Longitudinal Investigation (EARLI), which enrolled mothers who had an autistic child from a previous pregnancy and followed them through a subsequent pregnancy and until that child reached age 3 years. Maternal urine samples were collected during the second trimester of pregnancy and were later measured for levels of isoprostanes. Child neurodevelopmental assessments included the Mullen Scales of Early Learning (MSEL), the Social Responsiveness Scale (SRS), and the Vineland Adaptive Behavior Scale (VABS), and were conducted around 36 months of age. Primary analyses examined associations between interquartile range (IQR) increases in 8-iso-PGF2 alpha levels, and total composite scores from each assessment using quantile regression. In adjusted analyses, we did not observe statistically significant associations, though estimates suggested modestly lower cognitive scores ((3 for MSEL = -3.68, 95% CI: -10.09, 2.70), and minor increases in autism-related trait scores ((3 for SRS T score = 1.68, 95% CI: -0.24, 3.60) with increasing 8-iso-PGF2 alpha. These suggestive associations between decreased cognitive scores and increased autism-related traits with increasing prenatal oxidative stress point to the need for continued investigation in larger samples of the role of oxidative stress as a mechanistic pathway in autism and related neurodevelopmental outcomes.
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Details
- Title
- The association between prenatal oxidative stress levels measured by isoprostanes and offspring neurodevelopmental outcomes at 36 months
- Creators
- Meghan E. Carey - Drexel UniversityApollo Kivumbi - Drexel UniversityJuliette Rando - Drexel UniversityA. Clementina Mesaros - College Station Medical CenterStepan Melnyk - Arkansas Children's HospitalS. Jill James - University of Arkansas for Medical SciencesLisa A. Croen - Kaiser PermanenteHeather Volk - Johns Hopkins UniversityKristen Lyall - Drexel UniversityEarly Autism Risk Longitudinal Invest EARLI Team
- Publication Details
- Brain, behavior, & immunity. Health, v 38, 100775
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- R21HD096356 / Eunice Shriver Kennedy National Institute of Child Health and Human Development (NICHD) at the National Institutes of Health (NIH) National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) National Institute of Mental Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) National Institute of Child Health and Human Development; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) R01 ES016443; R24 ES030893 / National Institute of Neurologic Disease and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) AS 5938 / Autism Speaks
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics; A.J. Drexel Autism Institute
- Web of Science ID
- WOS:001287126100001
- Scopus ID
- 2-s2.0-85191313904
- Other Identifier
- 991021902500604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Neurosciences
- Psychiatry