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The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder
Journal article   Open access

The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder

Kimberly Berger, Michelle Pearl, Marty Kharrazi, Ying Li, Josephine DeGuzman, Jianwen She, Paramjit Behniwal, Kristen Lyall and Gayle Windham
Autism research, v 14(9), pp 2017-2026
01 Sep 2021
DOI: https://doi.org/10.1002/aur.2561
PMID: 34165248
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10752221View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Behavioral Sciences Life Sciences & Biomedicine Psychology Psychology, Developmental Science & Technology Social Sciences
Previous studies on in utero exposure to maternal environmental tobacco smoke (ETS) or maternal active smoking and Autism Spectrum Disorder (ASD) have not been entirely consistent, and no studies have examined in utero cotinine concentrations as an exposure classification method. We measured cotinine in stored second trimester maternal serum for 498 ASD cases and 499 controls born in California in 2011-2012. We also obtained self-reported maternal cigarette smoking during and immediately prior to pregnancy, as well as covariate data, from birth records. Using unconditional logistic regression, we found no association between log10 cotinine concentrations and odds for developing ASD among children of non-smokers (aOR: 0.93 [95% CI: 0.69, 1.25] per ng/ml), which represents exposure to ETS, though there may be a possible interaction with race. We found no association between cotinine-defined smoking (>= 3.08 ng/ml vs. <3.08 ng/ml) (adjusted odds ratio [aOR]: 0.73 (95% confidence interval [95% CI]: 0.35, 1.54)) or self-reported smoking (aOR: 1.64 [95% CI: 0.65, 4.16]) and ASD. In one of the few studies of ETS and the first with measured cotinine, our results indicate no overall relationship between in utero exposure to tobacco smoke from maternal ETS exposure or active smoking, and development of ASD. Lay Summary This study found that women who smoke or are exposed to tobacco smoke during pregnancy are not more likely to have children with Autism Spectrum Disorder (ASD). This is the first ASD study to measure a chemical in the mother's blood during pregnancy to identify exposure to tobacco smoke.

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9 citations in Web of Science
10 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Behavioral Sciences
Psychology, Developmental
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