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The influence of fatty acyl chain length and head group on the size of multilamellar vesicles
Journal article   Peer reviewed

The influence of fatty acyl chain length and head group on the size of multilamellar vesicles

Thomas J. Racey, Michael A. Singer, Leonard Finegold and Paul Rochon
Chemistry and physics of lipids, v 49(4)
1989
DOI: https://doi.org/10.1016/0009-3084(89)90074-1
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

chainlength liposomes phosphatidyl cholines quasi-elastic light scattering sizes
The aggregation properties of diacyl phosphatidyl cholines (PC) with symmetric chains of 8–18 carbons in length and diacyl phospholipids with differing head groups (PC versus phosphatidyl ethanolamine (PE) versus phosphatidyl glycerol (PG) were examined using the techniques of quasi-elastic light scattering (QELS) and freeze fracture microscopy. All of these lipids except for the short chain C8PC (where C8 denotes 8 carbon chains) and CPC form multilamellar vesicles. Within this series we observed a positive correlation between most probable vesicle size and acyl chain length. For lipids with identical acyl chains there was an inverse correlation between vesicle size and effective head group cross-sectional area. We envisage a scheme in which the size of liposomes is determined by the area and thickness of multilamellar sheets which occur upon hydration of the dried lipid.

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24 citations in Web of Science
20 citations in Scopus

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Domestic collaboration
International collaboration
Web of Science research areas
Biochemistry & Molecular Biology
Biophysics
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