Journal article
The limbic system-associated membrane protein is an Ig superfamily member that mediates selective neuronal growth and axon targeting
Neuron (Cambridge, Mass.), v 15(2), pp 287-297
1995
PMID: 7646886
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The formation of brain circuits requires molecular recognition between functionally related neurons. We report the cloning of a molecule that participates in these interactions. The limbic system-associated membrane protein (LAMP) is an immunoglobulin (Ig) super-family member with 3 Ig domains and a glycosyl-phosphatidylinositol anchor. In the developing forebrain,
lamp is expressed mostly by neurons comprising limbic-associated cortical and subcortical regions that function in cognition, emotion, memory, and learning. The unique distribution of LAMP reflects its functional specificity. LAMP-transfected cells selectively facilitate neurite outgrowth of primary limbic neurons. Most striking, administration of anti-LAMP in vivo results in abnormal growth of the mossy fiber projection from developing granule neurons in the dentate gyrus of the hippocampal formation, suggesting that LAMP is essential for proper targeting of this pathway. Rather than being a general guidance cue, LAMP likely serves as a recognition molecule for the formation of limbic connections.
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Details
- Title
- The limbic system-associated membrane protein is an Ig superfamily member that mediates selective neuronal growth and axon targeting
- Creators
- Aurea F. Pimenta - University of Medicine and Dentistry of New JerseyVictoria Zhukareva - University of Medicine and Dentistry of New JerseyMary F. Barbe - Temple UniversityBlesilda S. Reinoso - University of Medicine and Dentistry of New JerseyChristopher Grimley - GenentechWilliam Henzel - GenentechItzhak Fischer - Drexel UniversityPat Levitt - University of Medicine and Dentistry of New Jersey
- Publication Details
- Neuron (Cambridge, Mass.), v 15(2), pp 287-297
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1995RR42600007
- Scopus ID
- 2-s2.0-0029082199
- Other Identifier
- 991019184080404721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Neurosciences