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Accepted (AM)Open Access (License Unspecified), Open
Journal article
The nucleus acts as a ruler tailoring cell responses to spatial constraints
Science (American Association for the Advancement of Science), v 370(6514)
16 Oct 2020
PMID: 33060332
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The microscopic environment inside a metazoan organism is highly crowded. Whether individual cells can tailor their behavior to the limited space remains unclear. In this study, we found that cells measure the degree of spatial confinement by using their largest and stiffest organelle, the nucleus. Cell confinement below a resting nucleus size deforms the nucleus, which expands and stretches its envelope. This activates signaling to the actomyosin cortex via nuclear envelope stretch-sensitive proteins, up-regulating cell contractility. We established that the tailored contractile response constitutes a nuclear ruler-based signaling pathway involved in migratory cell behaviors. Cells rely on the nuclear ruler to modulate the motive force that enables their passage through restrictive pores in complex three-dimensional environments, a process relevant to cancer cell invasion, immune responses, and embryonic development.
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Details
- Title
- The nucleus acts as a ruler tailoring cell responses to spatial constraints
- Creators
- A J Lomakin - Institut CurieC J Cattin - Swiss Federal Institute of Technology in ZurichD Cuvelier - Institut Pierre-Gilles de Gennes pour la MicrofluidiqueZ Alraies - Institut CurieM Molina - King's College LondonG P F Nader - Institut Pierre-Gilles de Gennes pour la MicrofluidiqueN Srivastava - Institut Pierre-Gilles de Gennes pour la MicrofluidiqueP J Sáez - Institut Pierre-Gilles de Gennes pour la MicrofluidiqueJ M Garcia-Arcos - Institut Pierre-Gilles de Gennes pour la MicrofluidiqueI Y Zhitnyak - Russian Cancer Research Center NN BlokhinA Bhargava - Institut CurieM K Driscoll - The University of Texas Southwestern Medical CenterE S Welf - The University of Texas Southwestern Medical CenterR Fiolka - The University of Texas Southwestern Medical CenterR J Petrie - Drexel UniversityN S De Silva - Institut CurieJ M González-Granado - Research Institute Hospital 12 de OctubreN Manel - Institut CurieA M Lennon-Duménil - Institut CurieD J Müller - Swiss Federal Institute of Technology in ZurichM Piel - Institut Pierre-Gilles de Gennes pour la Microfluidique
- Publication Details
- Science (American Association for the Advancement of Science), v 370(6514)
- Publisher
- American Association for the Advancement of Science (AAAS)
- Grant note
- K99 GM123221 / NIGMS NIH HHS R35 GM133522 / NIGMS NIH HHS R01 GM126054 / NIGMS NIH HHS R33 CA235254 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000579179500052
- Scopus ID
- 2-s2.0-85093488857
- Other Identifier
- 991019167738104721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology