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Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
Theoretical Considerations in the Use of Dynamic Cardiomyoplasty to Treat Dilated Cardiomyopathy
Journal of cardiac surgery, v 6(1S), pp 119-123
Mar 1991
PMID: 1807493
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Abstract
Clinical data describing the hemodynamic benefits of cardiomyoplasty are inconclusive, and there has not been any study detailing the mechanisms by which dynamic cardiomyoplasty may improve the functional and mechanical Impairments of the falling heart. The left ventricle in dilated cardiomyopathy is characterized by increased end‐diastolic volume, inadequate systolic myocardial wall thickening, increased wall stress, and decreased stroke volume. Based on experimental and preliminary clinical data, we propose that cardiac assistance by dynamic cardiomyoplasty is the consequence of enhanced volume translocation rather than increased potential for pressure generation. A small augmentation of dimensional shortening results in a large increment of stroke volume because of the enlarged resting chamber volume. Key geometric effects are enhanced systolic chamber shortening and increased wall thickening, resulting in a net decrease of myocardial wall stress. The contractile skeletal muscle may improve myocardial mechanics, and normalization of the afterload mismatch may be an important mechanism by which dynamic cardiomyoplasty augments cardiac output.
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Details
- Title
- Theoretical Considerations in the Use of Dynamic Cardiomyoplasty to Treat Dilated Cardiomyopathy
- Creators
- K. Francis LeeCornelius M. DykeAndrew S. Wechsler
- Publication Details
- Journal of cardiac surgery, v 6(1S), pp 119-123
- Publisher
- Wiley
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; [Retired Faculty]
- Web of Science ID
- WOS:A1991FG81200008
- Scopus ID
- 2-s2.0-0025765849
- Other Identifier
- 991020705614804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Surgery