Journal article
Three-Dimensional Laser Flow Measurements of a Patient-Specific Fontan Physiology With Mechanical Circulatory Assistance
Artificial organs, v 39(6), pp E67-E78
01 Jun 2015
PMID: 25865262
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mechanical assistance of the Fontan circulation is hypothesized to enhance ventricular preload and improve cardiac output; however, little is known about the fluid dynamics. This study is the first to investigate the three-dimensional flow conditions of a blood pump in an anatomic Fontan. Laser measurements were conducted having an axial flow impeller in the inferior vena cava. Experiments were performed for a physiologic cardiac output, pulmonary arterial flows, and pump speeds of 1000-4000rpm. The impeller had a modest effect on the flow conditions entering the total cavopulmonary connection at low pump speeds, but a substantial impact on the velocity at higher speeds. The higher speeds of the pump disrupted the recirculation region in the center of the anastomosis, which could be advantageous for washout purposes. No retrograde velocities in the superior vena cava were measured. These findings indicate that mechanical assistance is a viable therapeutic option for patients having dysfunctional single ventricle physiology.
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Details
- Title
- Three-Dimensional Laser Flow Measurements of a Patient-Specific Fontan Physiology With Mechanical Circulatory Assistance
- Creators
- Steven G. Chopski - Virginia Commonwealth UniversityOwen M. Rangus - Virginia Commonwealth UniversityEmily A. Downs - Virginia Commonwealth UniversityWilliam B. Moskowitz - Virginia Commonwealth UniversityAmy L. Throckmorton - Virginia Commonwealth University
- Publication Details
- Artificial organs, v 39(6), pp E67-E78
- Publisher
- Wiley
- Number of pages
- 12
- Grant note
- U.S. Department of Education GAANN Interdisciplinary Graduate Engineering Education and Research (I-GEEAR) fellowship award
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000355768000001
- Scopus ID
- 2-s2.0-84930384243
- Other Identifier
- 991019168527104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Transplantation