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Three-Dimensional Laser Flow Measurements of a Patient-Specific Fontan Physiology With Mechanical Circulatory Assistance
Journal article   Open access   Peer reviewed

Three-Dimensional Laser Flow Measurements of a Patient-Specific Fontan Physiology With Mechanical Circulatory Assistance

Steven G. Chopski, Owen M. Rangus, Emily A. Downs, William B. Moskowitz and Amy L. Throckmorton
Artificial organs, v 39(6), pp E67-E78
01 Jun 2015
PMID: 25865262
url
https://doi.org/10.1111/aor.12426View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze) Open

Abstract

Engineering Engineering, Biomedical Life Sciences & Biomedicine Science & Technology Technology Transplantation
Mechanical assistance of the Fontan circulation is hypothesized to enhance ventricular preload and improve cardiac output; however, little is known about the fluid dynamics. This study is the first to investigate the three-dimensional flow conditions of a blood pump in an anatomic Fontan. Laser measurements were conducted having an axial flow impeller in the inferior vena cava. Experiments were performed for a physiologic cardiac output, pulmonary arterial flows, and pump speeds of 1000-4000rpm. The impeller had a modest effect on the flow conditions entering the total cavopulmonary connection at low pump speeds, but a substantial impact on the velocity at higher speeds. The higher speeds of the pump disrupted the recirculation region in the center of the anastomosis, which could be advantageous for washout purposes. No retrograde velocities in the superior vena cava were measured. These findings indicate that mechanical assistance is a viable therapeutic option for patients having dysfunctional single ventricle physiology.

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7 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Engineering, Biomedical
Transplantation
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