Journal article
Titin N2A Domain and Its Interactions at the Sarcomere
International journal of molecular sciences, v 22(14), p7563
01 Jul 2021
PMID: 34299183
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Titin is a giant protein in the sarcomere that plays an essential role in muscle contraction with actin and myosin filaments. However, its utility goes beyond mechanical functions, extending to versatile and complex roles in sarcomere organization and maintenance, passive force, mechanosensing, and signaling. Titin's multiple functions are in part attributed to its large size and modular structures that interact with a myriad of protein partners. Among titin's domains, the N2A element is one of titin's unique segments that contributes to titin's functions in compliance, contraction, structural stability, and signaling via protein-protein interactions with actin filament, chaperones, stress-sensing proteins, and proteases. Considering the significance of N2A, this review highlights structural conformations of N2A, its predisposition for protein-protein interactions, and its multiple interacting protein partners that allow the modulation of titin's biological effects. Lastly, the nature of N2A for interactions with chaperones and proteases is included, presenting it as an important node that impacts titin's structural and functional integrity.
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Details
- Title
- Titin N2A Domain and Its Interactions at the Sarcomere
- Creators
- Adeleye O. Adewale - Wayne State UniversityYoung-Hoon Ahn - Wayne State University
- Publication Details
- International journal of molecular sciences, v 22(14), p7563
- Publisher
- Mdpi
- Number of pages
- 18
- Grant note
- HL131740 / National Heart, Lung, and Blood Institute (NHLBI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Arts and Sciences; Chemistry; Drexel University
- Web of Science ID
- WOS:000676301200001
- Scopus ID
- 2-s2.0-85110073255
- Other Identifier
- 991020100053104721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary