Journal article
Transmural Gradient in High-Energy Phosphate Content in Patients with Coronary Artery Disease
The Annals of thoracic surgery, v 32(6), pp 546-553
Dec 1981
PMID: 6976154
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In 16 patients undergoing elective coronary artery bypass, transmural biopsies were performed during bypass but before global ischemia. Subendocardial and subepicardial halves were separately assayed in each sampled tissue. Adenosine triphosphate (ATP) levels, total adenine nucleotide content (ΣAd), and creatine phosphate (CP) content were significantly higher (
p < 0.005) in the subepicardium than the subendocardium in regions of the heart distal to major occlusions: 35.36 ± 2.12 nmole/mg versus 28.7 ± 1.7 (ATP), 42.24 ± 2.04 versus 35.6 ± 1.6 (ΣAd), and 29.99 ± 4.32 versus 16.35 ± 3.48 (CP). The opposite was true in two hearts with normal coronary arteries, in which high-energy phosphates tended to be higher in the subendocardium than the subepicardium. A transmural metabolic gradient therefore exists in regions of the myocardium distal to significant coronary occlusive disease. The subendocardium's relative depression in metabolic reserve could determine its susceptibility to ischemic damage and influence techniques designed to preserve the heart during ischemia.
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Details
- Title
- Transmural Gradient in High-Energy Phosphate Content in Patients with Coronary Artery Disease
- Creators
- Robert N. JonesRobert B. PeytonRichard L. SabinaJudith L. SwainEdward W. HolmesThomas L. SprayPeter Van TrigtAndrew S. Wechsler
- Publication Details
- The Annals of thoracic surgery, v 32(6), pp 546-553
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; [Retired Faculty]
- Web of Science ID
- WOS:A1981MV20000004
- Scopus ID
- 2-s2.0-0019835412
- Other Identifier
- 991020705435204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Respiratory System
- Surgery