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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Transplanting neural progenitor cells to restore connectivity after spinal cord injury
Nature reviews. Neuroscience, v 21(7), pp 366-383
01 Jul 2020
PMID: 32518349
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
There have been a number of recent advances in the use of transplanted cells to enable functional recovery in animal models of spinal cord injury. Fischer and colleagues review this work and describe the use of neural progenitor cell transplants to restore connectivity in key neural systems following spinal damage.
Spinal cord injury remains a scientific and therapeutic challenge with great cost to individuals and society. The goal of research in this field is to find a means of restoring lost function. Recently we have seen considerable progress in understanding the injury process and the capacity of CNS neurons to regenerate, as well as innovations in stem cell biology. This presents an opportunity to develop effective transplantation strategies to provide new neural cells to promote the formation of new neuronal networks and functional connectivity. Past and ongoing clinical studies have demonstrated the safety of cell therapy, and preclinical research has used models of spinal cord injury to better elucidate the underlying mechanisms through which donor cells interact with the host and thus increase long-term efficacy. While a variety of cell therapies have been explored, we focus here on the use of neural progenitor cells obtained or derived from different sources to promote connectivity in sensory, motor and autonomic systems.
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Details
- Title
- Transplanting neural progenitor cells to restore connectivity after spinal cord injury
- Creators
- Itzhak Fischer - Drexel UniversityJennifer N. Dulin - Texas A&M UniversityMichael A. Lane - Drexel University
- Publication Details
- Nature reviews. Neuroscience, v 21(7), pp 366-383
- Publisher
- Springer Nature
- Number of pages
- 18
- Grant note
- Mission Connect (a project of the TIRR Foundation) Craig H. Neilsen Foundation Louis and Bessie Stein Family grant Wings for Life Spinal Cord Research Foundation 2PO1 NS055976; R01 NS104291 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Paralyzed Veterans of America Research Foundation Lisa Dean Moseley Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000539706200001
- Scopus ID
- 2-s2.0-85086177352
- Other Identifier
- 991019168159804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences