Files and links (1)
Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Trends and patterns of antiseizure medication prescribing during pregnancy between 1995 and 2018 in the United Kingdom: A cohort study
BJOG : an international journal of obstetrics and gynaecology, v 131(1), pp 15-25
27 Aug 2024
PMID: 37340193
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
OBJECTIVE
To examine antiseizure medication (ASM) prescription during pregnancy.
DESIGN
Population-based drug utilisation study. SETTINGUK primary and secondary care data, 1995-2018, from the Clinical Practice Research Datalink GOLD version.
POPULATION OR SAMPLE
752 112 completed pregnancies among women registered for a minimum of 12 months with an 'up to standard' general practice prior to the estimated start of pregnancy and for the duration of their pregnancy.
METHODS
We described ASM prescription across the study period, overall and by ASM indication, examined patterns of prescription during pregnancy including continuous prescription and discontinuation, and used logistic regression to investigate factors associated with those ASM prescription patterns.
MAIN OUTCOME MEASURES
Prescription of ASMs during pregnancy and discontinuation of ASMs before and during pregnancy.
RESULTS
ASM prescription during pregnancy increased from 0.6% of pregnancies in 1995 to 1.6% in 2018, driven largely by an increase in women with indications other than epilepsy. Epilepsy was an indication for 62.5% of pregnancies with an ASM prescription and non-epilepsy indications were present for 66.6%. Continuous prescription of ASMs during pregnancy was more common in women with epilepsy (64.3%) than in women with other indications (25.3%). Switching ASMs was infrequent (0.8% of ASM users). Factors associated with discontinuation included age ≥35, higher social deprivation, more frequent contact with the GP and being prescribed antidepressants or antipsychotics.
CONCLUSIONS
ASM prescription during pregnancy increased between 1995 and 2018 in the UK. Patterns of prescription around the pregnancy period vary by indication and are associated with several maternal characteristics.
Metrics
Details
- Title
- Trends and patterns of antiseizure medication prescribing during pregnancy between 1995 and 2018 in the United Kingdom: A cohort study
- Creators
- Paul Madley-Dowd - University of BristolJessica Rast - Drexel UniversityViktor H Ahlqvist - Karolinska InstitutetCaichen Zhong - Drexel UniversityFlorence Z Martin - University of BristolNeil M Davies - University of BristolKristen Lyall - Drexel UniversityCraig Newschaffer - Pennsylvania State UniversityTorbjörn Tomson - Karolinska InstitutetCecilia Magnusson - Karolinska InstitutetDheeraj Rai - University of BristolBrian K Lee - Drexel UniversityHarriet Forbes - University of Bristol
- Publication Details
- BJOG : an international journal of obstetrics and gynaecology, v 131(1), pp 15-25
- Publisher
- Wiley
- Number of pages
- 11
- Grant note
- University of Bristol 218495/Z/19/Z / Wellcome Trust MC_UU_00011/3; MC_UU_00011/7; MC_UU_00011/1 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 1R01NS107607 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA NIHR Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust 295989 / Norwegian Research Council; Research Council of Norway MC_UU_00011/1; MC_ UU_00011/3; MC_UU_00011/7 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics; A.J. Drexel Autism Institute
- Web of Science ID
- WOS:001015482900001
- Scopus ID
- 2-s2.0-85162621420
- Other Identifier
- 991020624903604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Obstetrics & Gynecology