Journal article
Unusual phase properties of dilauryl phosphatidylcholine (C12PC)
Chemistry and physics of lipids, v 53(2), pp 177-184
1990
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aqueous dispersions of diacyl phosphatidylcholines (C
nPC) with linear saturated chains of
n ⩾ 13 carbons show only a single sharp thermal main transition peak by differential scanning calorimetry (d.s.c.). By contrast C12PC shows, in addition to a sharp peak (−1.8°C), a broad peak located at 5°C. We show by thin layer chromatography, proton and phosphorus nuclear magnetic resonance, and gas and high pressure liquid chromatography, that the broad peak is indeed an intrinsic property of C12PC and not due to an impurity. In mixtures of C12PC with C13PC, the main peaks suggest ideal mixing of the components, but C12PC/C4PC mixtures do not suggest ideal mixing. Mixtures of C12PC with lauric or myristic acids show an accentuation of the broad peak above about 5 mol% acid. Freeze fracture micrographs of C12PC at temperatures above those of the broad peak show smooth faces only, with no morphological evidence for a non-bilayer phase such as H
II. We conclude that the broad peak represents a transition from a new phase, intermediate between L
β, and L
α, to the fully disordered L
α state.
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Details
- Title
- Unusual phase properties of dilauryl phosphatidylcholine (C12PC)
- Creators
- Leonard Finegold - Drexel UniversityWalter A. Shaw - Avanti Polar LipidsMichael A. Singer - Queen's University
- Publication Details
- Chemistry and physics of lipids, v 53(2), pp 177-184
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1990CW24000005
- Scopus ID
- 2-s2.0-0025264086
- Other Identifier
- 991019174557004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics