Journal article
Vortical flow characteristics of mechanical cavopulmonary assistance: Pre- and post-swirl dynamics
Technology and health care, v 24(5), pp 627-638
14 Sep 2016
PMID: 27061388
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Surgical optimization of the cavopulmonary connection and pharmacological therapy for dysfunctional Fontan physiology continue to advance, but these treatment approaches only slow the progression of decline to end-stage heart failure. The development of a mechanical cavopulmonary assist device will provide a viable therapeutic option in the bridging of patients to transplant or to stabilization. We hypothesize that rotational blood flow, delivered by an implantable axial flow blood pump, could effectively assist the venous circulation in Fontan patients by mimicking vortical blood flow patterns in the cardiovascular system. This study investigated seven new models of mechanical cavopulmonary assistance (single and dual-pump assist), created combinations of pump designs that deliver counter rotating vortical flow conditions, and analyzed pump performance, velocity streamlines, swirling strength, and energy augmentation in the cavopulmonary circuit for each support scenario. The model having an axial clockwise-oriented impeller in the inferior vena cava and an axial counterclockwise-oriented impeller rotating in the superior vena cava outperformed all of the support scenarios by enhancing the energy of the cavopulmonary circulation an average of 10.3% over the entire flow range and a maximum of 27.4% at %the higher flow rates. This research will guide the development of axial flow blood pumps for Fontan patients and demonstrated the high probability of %a cardiovascular benefit using counter rotating pumps in a dual support scenario, but found that this is dependent upon the patient-specific cavopulmonary anatomy.
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Details
- Title
- Vortical flow characteristics of mechanical cavopulmonary assistance: Pre- and post-swirl dynamics
- Creators
- Amy L Throckmorton - Drexel UniversitySteven G Chopski - Drexel UniversityShravani N Birewar - Drexel UniversityTerence S Joa - Drexel UniversityPablo Huang - Drexel UniversityKevin K Whitehead - Children's Hospital of PhiladelphiaRandy M Stevens - St. Christopher's Hospital for ChildrenJ Yasha Kresh - Drexel University
- Publication Details
- Technology and health care, v 24(5), pp 627-638
- Publisher
- IOS Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; School of Biomedical Engineering, Science, and Health Systems; [Retired Faculty]
- Web of Science ID
- WOS:000384430400002
- Scopus ID
- 2-s2.0-84988565696
- Other Identifier
- 991019167781404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Health Care Sciences & Services