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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Women's posttraumatic stress symptoms and autism spectrum disorder in their children
Research in autism spectrum disorders, v 8(6), pp 608-616
01 Jun 2014
PMID: 24855487
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Maternal posttraumatic stress disorder (PTSD) may be associated with autism spectrum disorder (ASD) in offspring through multiple pathways: maternal stress may affect the fetus; ASD in children may increase risk of PTSD in mothers; and the two disorders may share genetic risk. Understanding whether maternal PTSD is associated with child's ASD is important for clinicians treating children with ASD, as PTSD in parents is associated with poorer family functioning. We examined the association of maternal PTSD with offspring ASD in a large US cohort (N ASD cases = 413, N controls = 42,868). Mother's PTSD symptoms were strongly associated with child's ASD (RR 4-5 PTSD symptoms = 1.98, 95% CI = 1.39, 2.81; RR 6-7 symptoms = 2.89, 95% CI = 2.00, 4.18). Clinicians treating persons with ASD should be aware of elevated risk of PTSD in the mother. Genetic studies should investigate PTSD risk alleles in relation to ASD. (C) 2014 Elsevier Ltd. All rights reserved.
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Details
- Title
- Women's posttraumatic stress symptoms and autism spectrum disorder in their children
- Creators
- Andrea L. Roberts - Harvard UniversityKarestan C. Koenen - Columbia UniversityKristen Lyall - Harvard UniversityAlberto Ascherio - Harvard UniversityMarc G. Weisskopf - Harvard University
- Publication Details
- Research in autism spectrum disorders, v 8(6), pp 608-616
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- R01CA050385 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) AS1788 / Autism Speaks R21ES019982 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) R01 CA050385 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01 MH078928 / NIMH NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01MH078928 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) P30 ES000002; R21 ES019982 / NIEHS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000336111200002
- Scopus ID
- 2-s2.0-84897400512
- Other Identifier
- 991020099918804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Education, Special
- Psychiatry
- Psychology, Developmental
- Rehabilitation