Publications list
Conference presentation
Optical properties of animal tissue as diabetes progresses
Availability date 22 Aug 2006
Drexel University. School of Biomedical Engineering, Science, and Health Systems. Biomedical Technology Showcase, 2006.
Diffuse photon density wave methodology in the near infrared range was used to calculate absorption and scattering in wounds of healthy and diabetic rats. Differences observed as diabetes progresses can be correlated to the delayed healing observed in diabetics.
Conference presentation
Availability date 21 Aug 2006
Drexel University. School of Biomedical Engineering, Science, and Health Systems. Biomedical Technology Showcase, 2006.
Inflammatory Bowel Disease affects nearly 1.5 million people. Currently, there are no efficient and reliable methods to quantify the degree of inflammation in these patients. The objective here was to image and quantify in an experimental model of colitis, MPO, IL1_ and TNF_ (proinflammatory cytokines) using Quantum Dots (QDs) conjugated with specific antibodies. The resulting fluorescence intensity was then used as a measure of concentration of MPO and in turn inflammation. The fluorescent images obtained from animals showed sequential increase in fluorescence intensity of MPO correlating (R = 0.96) with clinical disease. Fluorescent images also showed co-localization of all the three markers in both acute as well as chronic inflammation. These observations suggest that QD bioconjugates can be used nanotools to image biomarkers of inflammation.